Epigentic silencing of the glucocorticoid receptor in small cell lung cancer cells.
Small cell lung cancer (SCLC) is an aggressive neuroendocrine tumour which secretes ACTH and other related peptides. Contrary to normal production by the pituitary, ACTH production is not inhibited by glucocorticoids (Gcs) in SCLC. This insensitivity to Gc action can be attributed to impaired Gc rec...
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| Language: | en_ZA |
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2013
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| Online Access: | http://hdl.handle.net/10413/9855 |