Antioxidative, analgesic and anti-inflammatory activities of Acokanthera oppositifolia, Plantago lanceolata, Conyza canadensis, and Artemisia vulgaris

• Main Author: Ondua, Moise
• Other Authors: Lebelo, S. L.
• Format: Others
• Language: en
• Published: 2015
• Subjects: Plantago lanceolata; Conyza canadensis; Acokantera oppositifolia; Artemisia vulgaris; Antioxidant; Anti-inflammatory; Nitric oxide; Cell viability; Raw 264.7 macrophages; Lypoxygenase; Cyclooxygenase-1; Cyclooxygenase-2; 615.321; Antioxidants; Analgesics; Anti-inflammatory agents|; Medicinal plants; Medicinal plants > South Africa > Research
• Online Access: Ondua, Moise (2015) Antioxidative, analgesic and anti-inflammatory activities of Acokanthera oppositifolia, Plantago lanceolata, Conyza canadensis, and Artemisia vulgaris, University of South Africa, Pretoria, <http://hdl.handle.net/10500/19169>; http://hdl.handle.net/10500/19169

The anti-inflammatory properties of four medicinal plants were investigated. These plant extracts were subjected to screening for their possible effects as antioxidative, analgesic, and anti-inflammatory agents. In the antioxidant activity, the Plantago lancelota extracts resulted in an IC50 value of 0.4 mg/mL compared to the positive control quecertin with IC50 0.04 mg/mL Plantago lanceolata inhibited COX-2 activity with IC50 values of 0.41 mg/mL. However, the COX-1 inhibition indicated an IC50 of 68.99 mg/mL. The lipoxygenase assay indicated that Plantago lanceolata was the most active plant species with an IC50 value of 4.86 mg/mL compared to the positive control (quecertin) with an IC50<2mg/mL. The nitric oxide assay of the plant extracts indicates a dose-dependent activity of our plant extracts. Likewise the cell viability result indicated a good activity at dose 100 mg/mL. === Life and Consumer Sciences === M. Sc. (Life Sciences)