Effect of cytochrome P450 inhibition on pharmacokinetics and toxicity of diclofenac in chickens : unravelling toxicity in Gyps vultures

Effect of cytochrome P450 inhibition on pharmacokinetics and toxicity of diclofenac in chickens : unravelling toxicity in Gyps vultures

The nonsteroidal anti-inflammatory drug (NSAID) diclofenac was responsible for the decimation of Gyps vulture species on the Indian subcontinent over the last two decades of the 20th century. For an unknown reason, Gyps vultures were extremely sensitive to diclofenac (LD50 ~ 0.1-0.2 mg/kg), with tox...

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Bibliographic Details
Main Author: Locke, Sara Lindsey
Other Authors: Naidoo, Vinny
Language:en
Published: University of Pretoria 2020
Subjects:
UCTD
Veterinary Pharmacology
Online Access:http://hdl.handle.net/2263/75858
Locke, SL 2020, Effect of Cytochrome P450 Inhibition on Pharmacokinetics and Toxicity of Diclofenac in Chickens: Unravelling Toxicity in Gyps Vultures, MSc Mini Dissertation, University of Pretoria, Pretoria, viewed yymmdd <http://hdl.handle.net/2263/75858>

Internet

http://hdl.handle.net/2263/75858
Locke, SL 2020, Effect of Cytochrome P450 Inhibition on Pharmacokinetics and Toxicity of Diclofenac in Chickens: Unravelling Toxicity in Gyps Vultures, MSc Mini Dissertation, University of Pretoria, Pretoria, viewed yymmdd <http://hdl.handle.net/2263/75858>

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