Massively-Parallel Computational Identification of Novel Broad Spectrum Antivirals to Combat Coronavirus Infection

Massively-Parallel Computational Identification of Novel Broad Spectrum Antivirals to Combat Coronavirus Infection

Philosophiae Doctor - PhD === Given the significant disease burden caused by human coronaviruses, the discovery of an effective antiviral strategy is paramount, however there is still no effective therapy to combat infection. This thesis details the in silica exploration of ligand libraries to ident...

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Bibliographic Details
Main Author: Berry, Michael
Other Authors: Gamieldien, Junaid
Language:en
Published: University of the Western Cape 2021
Subjects:
Human coronaviruses
3 Chymotrypsin like protease
Structure based drug design
Ligand based drug design
High throughput virtual screening
Molecular docking
Pharmacophore modelling
Molecular dynamics
Lead discovery
Online Access:http://hdl.handle.net/11394/8321

Internet

http://hdl.handle.net/11394/8321

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