Stabilita vitamínů ve směsích pro parenterální výživu

• Main Author: Khýnová, Lucie
• Other Authors: Solich, Petr
• Format: Dissertation
• Language: English
• Published: 2009
• Online Access: http://www.nusl.cz/ntk/nusl-279151

Parenteral Nutrition (PN) is an alternative method of providing nutritional support for patients via the intravenous route. Patients selected for PN are malnourished patients or patients who have the potential to become malnourished. PN admixtures consist of fats, carbohydrates, proteins, vitamins, trace elements, electrolytes and fluids. Vitamins are believed to be among the least stable ingredients in PN mixtures and should be added immediately before commencing infusion. The purpose of this thesis is to obtain information on stability of the vitamins in PN admixtures depending on different storage conditions and different time. Water-soluble vitamins and fat-soluble vitamins were investigated in the mixture of Kabiven® Bag (Fresenius Kabi) with Vitlipid® N (fat-soluble vitamins) and Solvitio® N water-soluble vitamins) Adult Injections. There were prepared 6 Bags altogether, three with addition of trace elements contained in Additrace® concentrate and three Bags without trace elements. Assessing the chemical and physical stability was carried out after: zero time, 7, 14 and 29 days in a refrigerator followed by 24 hours and 48 hours storage at ambient temperature and day-light protected. Physical tests include pH, osmolality, microscopy and particle size determination by laser diffraction....