Syntéza konjugátů oligonukleotidů s molekulami zvyšujícími pevnost vazby na řetězce nukleových kyselin
Distamycin A, netropsin, Hoechst 33258 and other are substances that bind in minor groove in the double helix of A·T base pairs DNA sequences. This diploma thesis describes the synthesis of compounds structurally derived from the model molecule distamycin A and their conjugation with oligonucleotide...
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| Format: | Dissertation |
| Language: | Czech |
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2011
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| Online Access: | http://www.nusl.cz/ntk/nusl-297659 |