Genetic studies of collagen types XV and XVIII:type XV collagen deficiency in mice results in skeletal myopathy and cardiovascular defects, while the homologous endostatin precursor type XVIII collagen is needed for normal development of the eye
Abstract Overlapping genomic clones coding for the α1 chain of mouse type XV collagen (Col15a1) were isolated. The gene was found to be 110 kb in length and to contain 40 exons. Analysis of the proximal 5'-flanking region showed properties characteristic of a housekeeping gene promoter, an...
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| Format: | Doctoral Thesis |
| Language: | English |
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University of Oulu
2001
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| Online Access: | http://urn.fi/urn:isbn:9514265793 http://nbn-resolving.de/urn:isbn:9514265793 |