Mechanism of benzo(a)pyrene-induced accumulation of p53 tumour suppressor protein in mouse
Abstract The tumour suppressor gene TP53 is the most commonly mutated gene in human cancers. The protein it codes, p53, becomes activated as a response to stress signals. When activated, p53 binds to DNA and affects the transcription of its target genes. They then cause cell cycle arrest, DNA repai...
| Main Author: | |
|---|---|
| Format: | Doctoral Thesis |
| Language: | English |
| Published: |
University of Oulu
2003
|
| Subjects: | |
| Online Access: | http://urn.fi/urn:isbn:9514270398 http://nbn-resolving.de/urn:isbn:9514270398 |