Assembly and secretion of recombinant human collagens and gelatins in the yeast <em>Pichia pastoris</em>, and generation and analysis of knock-out mice for collagen prolyl 4-hydroxylase type I
Abstract Collagen molecules consist of three polypeptide chains that are coiled around each other to form a triple-helical structure. The formation of stable collagen triple helices requires the hydroxylation of proline residues catalyzed by collagen prolyl 4-hydroxylases (C-P4H). Vertebrate C-P4H...
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| Format: | Doctoral Thesis |
| Language: | English |
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University of Oulu
2006
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| Online Access: | http://urn.fi/urn:isbn:9514281047 http://nbn-resolving.de/urn:isbn:9514281047 |