Modulation of the Cardiac Calcium Release Channel by Homocysteine Thiolactone

Elevated levels in blood serum (≥10μmol/L) of the amino acid homocysteine is strongly correlated with the incidence of heart failure (HF). We present evidence that the cyclic thioester, homocysteine thiolactone (HTL), a metabolic product of homocysteine, irreversibly modifies proteins that regulate...

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Bibliographic Details
Main Author: Owen, Laura Jean
Format: Others
Published: PDXScholar 2014
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