Modulation of the Cardiac Calcium Release Channel by Homocysteine Thiolactone
Elevated levels in blood serum (≥10μmol/L) of the amino acid homocysteine is strongly correlated with the incidence of heart failure (HF). We present evidence that the cyclic thioester, homocysteine thiolactone (HTL), a metabolic product of homocysteine, irreversibly modifies proteins that regulate...
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| Format: | Others |
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PDXScholar
2014
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| Online Access: | https://pdxscholar.library.pdx.edu/open_access_etds/2071 https://pdxscholar.library.pdx.edu/cgi/viewcontent.cgi?article=3071&context=open_access_etds |