The molecular mechanisms involved in the genetic instability of the CCTG. CAGG repeats associated with myotonic dystrophy type 2

The molecular mechanisms involved in the genetic instability of the CCTG. CAGG repeats associated with myotonic dystrophy type 2

Myotonic dystrophy type 2 (DM2) is caused by the extreme expansion (from < 30 repeats in normal individuals to ~ 11,000 for the full mutation in certain patients) of the repeating tetranucleotide CCTG•CAGG sequence in the intron of the zinc finger protein 9 (ZNF9) gene. The genetic instabilities...

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Bibliographic Details
Main Author: Dere, Ruhee J.
Other Authors: Wells, Robert D.
Format: Others
Language:en_US
Published: Texas A&M University 2006
Subjects:
DM2
Genetic instability
molecular mechanisms
Online Access:http://hdl.handle.net/1969.1/3783

Internet

http://hdl.handle.net/1969.1/3783

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