Investigation on chemical steps of thymidylate synthase catalyzed reaction
Thymidylate synthase (TS) catalyzes the reductive methylation of 2'-deoxyuridylate (dUMP) with cofactor 5,10-methylene-5, 6, 7, 8-tetrahydrofolate, forming thymidine monophosphate (dTMP) and 7, 8-dihydrofolate. The reaction pathway is comprised of at least seven covalent bond cl...
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| Format: | Others |
| Language: | English |
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University of Iowa
2007
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| Online Access: | https://ir.uiowa.edu/etd/125 https://ir.uiowa.edu/cgi/viewcontent.cgi?article=1310&context=etd |