Toxic intermediates and protein quality control in the polyglutamine disease, SCA3

Toxic intermediates and protein quality control in the polyglutamine disease, SCA3

Polyglutamine (polyQ) diseases are progressive fatal neurodegenerative movement disorders. Although many cellular processes are perturbed in polyQ disease, recent studies highlight the importance of protein misfolding as a central event in polyQ toxicity. Spinocerebellar ataxia type 3 (SCA3), also k...

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Bibliographic Details
Main Author: Williams, Aislinn Joanmarie
Other Authors: Paulson, Henry L.
Format: Others
Language:English
Published: University of Iowa 2010
Subjects:
ataxia
neurodegeneration
polyglutamine
protein folding
trinucleotide repeat
Neuroscience and Neurobiology
Online Access:https://ir.uiowa.edu/etd/624
https://ir.uiowa.edu/cgi/viewcontent.cgi?article=1809&context=etd

Internet

https://ir.uiowa.edu/etd/624
https://ir.uiowa.edu/cgi/viewcontent.cgi?article=1809&context=etd

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