Adaptive designs for dose response studies
This thesis is motivated by an adaptive design which was developed to inoculate healthy volunteers with nontypeable Haemophilus influenzae. The goal was to estimate the doses at which 50% (HCD50) and 90% (HCD90) of subjects became colonized. A fifteen-subject study was designed in two stages, with t...
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| Format: | Others |
| Language: | English |
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University of Iowa
2010
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| Online Access: | https://ir.uiowa.edu/etd/652 https://ir.uiowa.edu/cgi/viewcontent.cgi?article=1837&context=etd |