Novel bisphosphonates as inhibitors of isoprenoid biosynthesis
Products of the isoprenoid biosynthetic pathway are involved in diverse biological functions. For example, the isoprenoid diphosphate, farnesyl diphosphate (FPP), is used for synthesis of squalene, a precursor of cholesterol. In addition, FPP and geranylgeranyl diphosphate (GGPP) are used for protei...
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| Language: | English |
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University of Iowa
2011
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| Online Access: | https://ir.uiowa.edu/etd/2657 https://ir.uiowa.edu/cgi/viewcontent.cgi?article=4786&context=etd |