Structural features of fluoroquinolone-class antibiotics that affect lethal activities and DNA binding
Fluoroquinolones, broad-spectrum bactericidal antibiotics, exert their effects by inhibiting type II topoisomerases through the formation of a fluoroquinolone-DNA-topoisomerase ternary complex. Recently, newer, structurally unique fluoroquinolones have been shown to kill bacteria by promoting chromo...
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| Format: | Others |
| Language: | English |
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University of Iowa
2012
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| Online Access: | https://ir.uiowa.edu/etd/1395 https://ir.uiowa.edu/cgi/viewcontent.cgi?article=5434&context=etd |