Cytochrome P450-mediated drug metabolizing activity in the nasal mucosa
Pre-systemic elimination by local enzymatic degradation can play a key role in limiting the bioavailability of intranasally administered drugs. Despite remarkable advancement in the characterization of the nasal biotransformative enzymes, knowledge of the role of the nasal mucosa in limiting bioavai...
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| Format: | Others |
| Language: | English |
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University of Iowa
2013
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| Online Access: | https://ir.uiowa.edu/etd/1585 https://ir.uiowa.edu/cgi/viewcontent.cgi?article=5637&context=etd |