Structural and functional consequences of single mutations at the high affinity binding site of cyanovirin-N
This thesis focuses mainly on the consequences that single mutations have on structural, functional and energetic aspects of the protein cyanovirin-N. In order to estimate the free energy of single mutations, we have applied thermodynamics integration and Bennett acceptance ratio techniques. Replica...
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| Format: | Others |
| Language: | English |
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University of Iowa
2016
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| Online Access: | https://ir.uiowa.edu/etd/3133 https://ir.uiowa.edu/cgi/viewcontent.cgi?article=6477&context=etd |