Auto-inhibition mechanism of the guanine nucleotide exchange factor Tiam1

The Rho family of guanosine triphosphatases (GTPases) function as binary molecular switches, which play an important role in the regulation of actin cytoskeleton rearrangement and are involved in several critical cellular processes including cell adhesion, division and migration. Rho GTPases are spe...

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Bibliographic Details
Main Author: Xu, Zhen
Other Authors: Fuentes, Ernesto Jorge, 1966-
Format: Others
Language:English
Published: University of Iowa 2016
Subjects:
Online Access:https://ir.uiowa.edu/etd/5880
https://ir.uiowa.edu/cgi/viewcontent.cgi?article=7358&context=etd