Destabilizing NEK2 overcomes resistance to proteasome inhibition in multiple myeloma
Multiple Myeloma (MM) is an incurable plasma cell malignancy and, although novel treatment regimes in the past decade have improved patient outcome, long-term treatment leads to relapse and refractory disease. The centrosomal kinase NEK2 is found overexpressed in MM and promotes chromosomal instabil...
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| Format: | Others |
| Language: | English |
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University of Iowa
2018
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| Online Access: | https://ir.uiowa.edu/etd/6104 https://ir.uiowa.edu/cgi/viewcontent.cgi?article=7799&context=etd |