Specificity, structure, dynamics and inhibition of the Tiam PDZ domain/ligand complexes
The T-cell lymphoma invasion and metastasis (Tiam) family of proteins are guanine nucleotide exchange factors (GEFs). The Tiam family has two homologs, Tiam1 and Tiam2, which activate the Rho-family GTPase Rac1 and are crucial for cell-cell adhesion. Tiam1/2 contain several protein-protein interacti...
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| Format: | Others |
| Language: | English |
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University of Iowa
2014
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| Online Access: | https://ir.uiowa.edu/etd/6605 https://ir.uiowa.edu/cgi/viewcontent.cgi?article=8104&context=etd |