INTEGRIN α6β4 PROMOTES PANCREATIC CANCER INVASION BY ALTERING DNA REPAIR-MEDIATED EPIGENETICS
Integrin α6β4 is upregulated in pancreatic carcinoma, where signaling promotes metastatic properties, in part by altering the transcriptome. Such alterations can be accomplished through DNA demethylation of specific promoters, as seen with the pro-metastatic gene S100A4. I found that signaling from...
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| Format: | Others |
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UKnowledge
2016
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| Online Access: | http://uknowledge.uky.edu/biochem_etds/27 http://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1026&context=biochem_etds |