SINGLE-MOLECULE ANALYSIS OF ALZHEIMER'S β-PEPTIDE OLIGOMER DISASSEMBLY AT PHYSIOLOGICAL CONCENTRATION

SINGLE-MOLECULE ANALYSIS OF ALZHEIMER'S β-PEPTIDE OLIGOMER DISASSEMBLY AT PHYSIOLOGICAL CONCENTRATION

The diffusible soluble oligomeric amyloid β-peptide (Aβ) has been identified as a toxic agent in Alzheimer’s disease that can cause synaptic dysfunction and memory loss, indicating its role as potential therapeutic targets for AD treatment. Recently an oligomer-specific sandwich biotin-avidin intera...

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Bibliographic Details
Main Author: Chen, Chen
Format: Others
Published: UKnowledge 2014
Subjects:
Alzheimer’s disease
soluble amyloid-β oligomers
Aβ
oligomer dissociators
fluorescence correlation spectroscopy
atomic force microscopy
dissociation mechanism
Biochemistry
Biophysics
Online Access:http://uknowledge.uky.edu/chemistry_etds/31
http://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1033&context=chemistry_etds

Internet

http://uknowledge.uky.edu/chemistry_etds/31
http://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1033&context=chemistry_etds

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