ILLUMINATING DNA PACKAGING IN SPERM CHROMATIN: HOW POLYCATION LENGTHS, UNDERPROTAMINATION AND DISULFIDE LINKAGES ALTERS DNA CONDENSATION AND STABILITY

ILLUMINATING DNA PACKAGING IN SPERM CHROMATIN: HOW POLYCATION LENGTHS, UNDERPROTAMINATION AND DISULFIDE LINKAGES ALTERS DNA CONDENSATION AND STABILITY

During spermiogenesis, somatic chromatin is remodeled and a vast majority (> 90%) of DNA histones are replaced by short arginine-rich peptides called protamines. This compaction is immense, with protamine-DNA self-assembly in sperm chromatin resulting in a final volume roughly 1/6th of a somatic...

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Bibliographic Details
Main Author: Kirchhoff, Daniel
Format: Others
Published: UKnowledge 2019
Subjects:
Sperm Chromatin
Protamine
Disulfide Linkages
Underprotamination
DNA condensation
DNA Damage
Biochemistry
Online Access:https://uknowledge.uky.edu/chemistry_etds/112
https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1122&context=chemistry_etds

Internet

https://uknowledge.uky.edu/chemistry_etds/112
https://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1122&context=chemistry_etds

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