LACTONE-CARBOXYLATE INTERCONVERSION AS A DETERMINANT OF THE CLEARANCE AND ORAL BIOAVAILABILTY OF THE LIPOPHILIC CAMPTOTHECIN ANALOG AR-67

LACTONE-CARBOXYLATE INTERCONVERSION AS A DETERMINANT OF THE CLEARANCE AND ORAL BIOAVAILABILTY OF THE LIPOPHILIC CAMPTOTHECIN ANALOG AR-67

The third generation camptothecin analog, AR-67, is undergoing early phase clinical trials as a chemotherapeutic agent. Like all camptothecins it undergoes pH dependent reversible hydrolysis between the lipophilic lactone and the hydrophilic carboxylate. The physicochemical differences between the l...

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Bibliographic Details
Main Author: Adane, Eyob Debebe
Format: Others
Published: UKnowledge 2010
Subjects:
AR-67
interconversion
lactone
carboxylate
P-gp
BCRP/Bcrp
OATP/Oatp
inverse Gaussian
Medicine and Health Sciences
Online Access:http://uknowledge.uky.edu/gradschool_diss/47
http://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1050&context=gradschool_diss

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http://uknowledge.uky.edu/gradschool_diss/47
http://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1050&context=gradschool_diss

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