LOBELANE ANALOGS WITH VARIOUS METHYLENE LINKER LENGTHS AND ACYCLIC LOBELANE ANALOGS AS POTENTIAL PHARMACOTHERAPIES TO TREAT METHAMPHETAMINE ABUSE

LOBELANE ANALOGS WITH VARIOUS METHYLENE LINKER LENGTHS AND ACYCLIC LOBELANE ANALOGS AS POTENTIAL PHARMACOTHERAPIES TO TREAT METHAMPHETAMINE ABUSE

Methamphetamine interacts with vesicular monoamine transporter-2 (VMAT2) to inhibit dopamine (DA) uptake and promotes DA release from presynaptic vesicles, increasing cytosolic DA available for methamphetamine-induced reverse transport by DA transporters. By inhibiting VMAT2, lobelane, a defunctiona...

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Bibliographic Details
Main Author: Cao, Zheng
Format: Others
Published: UKnowledge 2014
Subjects:
Lobeline
Lobelane
Methamphetamine
Vesicular Monoamine Tranporter-2
(R)-GZ-924
Other Pharmacy and Pharmaceutical Sciences
Online Access:http://uknowledge.uky.edu/pharmacy_etds/32
http://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1033&context=pharmacy_etds

Internet

http://uknowledge.uky.edu/pharmacy_etds/32
http://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1033&context=pharmacy_etds

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