NOVEL MECHANISM LEADING TO MISMATCH REPAIR DEFICIENCY AND MUTATOR PHENOTYPE

NOVEL MECHANISM LEADING TO MISMATCH REPAIR DEFICIENCY AND MUTATOR PHENOTYPE

DNA mismatch repair (MMR) is a critical genome-maintenance system. It ensures genome stability by correcting mismatches generated during DNA replication, suppressing homologous recombination, and inducing apoptosis in response to severe DNA damage. As a result, defects in MMR lead to genome-wide mut...

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Bibliographic Details
Main Author: Rodríguez, Janice Ortega
Format: Others
Published: UKnowledge 2012
Subjects:
PCNA
MutLα
Phosphorylation
HNPCC
AML
Medical Toxicology
Online Access:http://uknowledge.uky.edu/toxicology_etds/1
http://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1000&context=toxicology_etds

Internet

http://uknowledge.uky.edu/toxicology_etds/1
http://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1000&context=toxicology_etds

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