NOVEL MECHANISM LEADING TO MISMATCH REPAIR DEFICIENCY AND MUTATOR PHENOTYPE
DNA mismatch repair (MMR) is a critical genome-maintenance system. It ensures genome stability by correcting mismatches generated during DNA replication, suppressing homologous recombination, and inducing apoptosis in response to severe DNA damage. As a result, defects in MMR lead to genome-wide mut...
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UKnowledge
2012
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Online Access: | http://uknowledge.uky.edu/toxicology_etds/1 http://uknowledge.uky.edu/cgi/viewcontent.cgi?article=1000&context=toxicology_etds |