Macroscopic modelling of hybridoma cell fed-batch cultures with overflow metabolism: model-based optimization and state estimation

Macroscopic modelling of hybridoma cell fed-batch cultures with overflow metabolism: model-based optimization and state estimation

Monoclonal antibodies (MAbs) have an expanding market for use in diagnostic and therapeutic applications. Industrial production of these biopharmaceuticals is usually achieved based on fed-batch cultures of mammalian cells in bioreactors (Chinese hamster ovary (CHO) and Hybridoma cells), which can e...

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Bibliographic Details
Main Author: Amribt, Zakaria
Other Authors: Bogaerts, Philippe
Format: Doctoral Thesis
Language:en
Published: Universite Libre de Bruxelles 2014
Subjects:
Contrôle des matériaux
Cell culture
Hybridomas
Cellules > Culture
Hybridomes
State estimation
Bioprocess optimization
Overflow metabolism
Macroscopic modelling
Mammalian cell cultures
Hybridoma cultures
Online Access:http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209279

Internet

http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209279

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