Inference of gene networks from time series expression data and application to type 1 Diabetes

Inference of gene networks from time series expression data and application to type 1 Diabetes

The inference of gene regulatory networks (GRN) is of great importance to medical research, as causal mechanisms responsible for phenotypes are unravelled and potential therapeutical targets identified. In type 1 diabetes, insulin producing pancreatic beta-cells are the target of an auto-immune atta...

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Bibliographic Details
Main Author: Lopes, Miguel
Other Authors: Bontempi, Gianluca
Format: Doctoral Thesis
Language:en
Published: Universite Libre de Bruxelles 2015
Subjects:
Informatique générale
inference assessment
type 1 diabetes
causal inference
network inference
precision-recall curves
Online Access:http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/216729

Internet

http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/216729

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