Targeting Drug Resistance In HCV NS3/4A Protease: Mechanisms And Inhibitor Design Strategies

Targeting Drug Resistance In HCV NS3/4A Protease: Mechanisms And Inhibitor Design Strategies

The Hepatitis C virus (HCV) NS3/4A protease inhibitors (PIs) have become a mainstay of newer all-oral combination therapies. Despite improvements in potency of this inhibitor class, drug resistance remains a problem with the rapid emergence of resistance-associated substitutions (RASs). In this thes...

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Bibliographic Details
Main Author: Matthew, Ashley N.
Format: Others
Published: eScholarship@UMMS 2018
Subjects:
Hepacivirus
NS3/4A Protease
Viral Nonstructural Proteins
Protease Inhibitors
Hepatitis C virus
Drug Resistance
Biochemistry
Biophysics
Structural Biology
Online Access:https://escholarship.umassmed.edu/gsbs_diss/969
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1975&context=gsbs_diss

Internet

https://escholarship.umassmed.edu/gsbs_diss/969
https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1975&context=gsbs_diss

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