Novel Insight into the Autophagy-Independent Functions of Beclin 1 in Tumor Growth
BECN1 is a haploinsufficient tumor suppressor gene that is monoallelically deleted or epigenetically silenced in many human cancers. In breast cancer, 40% of tumors exhibit monoallelic deletion of Beclin 1. Additionally, low Beclin 1 mRNA expression is observed in aggressive breast cancer subtypes a...
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| Format: | Others |
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eScholarship@UMMS
2019
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| Online Access: | https://escholarship.umassmed.edu/gsbs_diss/1038 https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=2047&context=gsbs_diss |