HIV-1 Evasion of Human TRIM5α via Cyclophilin A
The abundant cellular protein Cyclophilin A (CypA) was found to bind to HIV-1 capsid (CA) in 1993. Since that time, several complementary methods, including disruption of the binding interface by cyclosporine A, CA mutants, and CypA mutants, have been used to demonstrate that CypA acts within human...
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| Format: | Others |
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eScholarship@UMMS
2020
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| Online Access: | https://escholarship.umassmed.edu/gsbs_diss/1089 https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=2098&context=gsbs_diss |