Age-dependent rAAV Mediated Reconstitution of hASPA Reveals N-acetylaspartate Regulates Fuel Selection in the Central Nervous System
N-acetylaspartate (NAA) is one of the most abundant molecules in the mammalian central nervous system (CNS). The current paradigm suggests that NAA is synthesized in neurons by the enzyme N-acetyltransferase 8-like (NAT8L) and hydrolyzed into aspartate and acetate by the enzyme aspartoacylase (ASPA)...
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| Format: | Others |
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eScholarship@UMMS
2020
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| Online Access: | https://escholarship.umassmed.edu/gsbs_diss/1110 https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=2119&context=gsbs_diss |