Chromosome 21 Dosage Effects in Down Syndrome by “Trisomy Silencing” Reveals Impairment of Angiogenic and Neurogenic Processes
Maintenance of gene dosage is important for proper cellular function and development, as evidenced by the natural silencing of one X-chromosome in mammalian females, and by the embryonic lethality of most autosomal aneuploidy. A notable exception is Down syndrome (DS), which occurs in 1/700 newborns...
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| Format: | Others |
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eScholarship@UMMS
2021
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| Online Access: | https://escholarship.umassmed.edu/gsbs_diss/1152 https://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=2161&context=gsbs_diss |