A high-complexity lentiviral shRNA screen identifies synthetic lethal interactions with deregulated N-Myc in neuroblastoma cells
In contrast to c-Myc, a deregulated expression of the MYCN gene is restricted to human neuroendocrine tumours. In most cases, the excessive activity of N-Myc results from a MYCN amplification. In neuroblastoma, amplification of MYCN is a predictor of poor prognosis and resistance to therapy. The ina...
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| Format: | Doctoral Thesis |
| Language: | English |
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2014
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| Online Access: | https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/10315 http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-103157 https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-103157 https://opus.bibliothek.uni-wuerzburg.de/files/10315/Xu_Jiajia_Doktorarbeit.pdf |