Development and characterization of monoclonal antibodies to GDF-15 for potential use in cancer therapy
Background GDF-15 is a divergent member of the TGF-superfamily, which was first described as macrophage inhibitory cytokine-1 (MIC-1), revealing an immune modulatory function. GDF-15 is a soluble protein which is, under physiological conditions, highly expressed in the placenta and found in elevate...
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| Format: | Doctoral Thesis |
| Language: | English |
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2015
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| Online Access: | https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/13242 http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-132424 https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-132424 https://opus.bibliothek.uni-wuerzburg.de/files/13242/JUNKER_MARKUS_GDF15.pdf |