The α-galactosidase A deficient mouse as a model for Fabry disease and the effect of Gb3 depositions on peripheral nociceptive ion channel function
Fabry disease (FD) is an X-linked lysosomal storage disorder with intracellular accumulation of globotriaosylceramide (Gb3) due to α-galactosidase A deficiency. We studied α-galactosidase A knockout mice (GLA KO) as a model for sensory disturbance and pain in FD. Pain associated behavior of young...
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| Format: | Doctoral Thesis |
| Language: | English |
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2018
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| Online Access: | https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/15851 http://nbn-resolving.de/urn:nbn:de:bvb:20-opus-158513 https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-158513 https://opus.bibliothek.uni-wuerzburg.de/files/15851/Lukas_Hofmann_Fabry_Disease.pdf |