HIF1α regulates Mitochondrial biogenesis and Cellular senescence induced by Gamma Radiation
Cellular response to γ-rays is mediated by ATM-p53 axis. When p53 is phosphorylated, it can transactivate several genes to induce permanent cell cycle arrest (senescence) or apoptosis. Epithelial and mesenchymal cells are more resistant to radiation-induced apoptosis and respond mainly by activating...
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Doctoral Thesis |
| Language: | en |
| Published: |
Alma Mater Studiorum - Università di Bologna
2013
|
| Subjects: | |
| Online Access: | http://amsdottorato.unibo.it/5794/ |