Tumor microenvironment as a target of osteolytic metastases
Bone is one of the most common sites of distant metastases from breast carcinoma. In lytic bone metastasis, tumor associated-osteoclasts are the main actors of bone resorption. Under physiological conditions, osteoclast formation is activated by cytokines and hormones produced by bone-resident cells...
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| Format: | Doctoral Thesis |
| Language: | en |
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Alma Mater Studiorum - Università di Bologna
2016
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| Online Access: | http://amsdottorato.unibo.it/7587/ |