Synthesis and Spectroscopic Study of Anticancer agent A-007 Prodrugs and Progress Towards the Synthesis of Tetramic acid Antibiotics

Synthesis and Spectroscopic Study of Anticancer agent A-007 Prodrugs and Progress Towards the Synthesis of Tetramic acid Antibiotics

4, 4'-Dihydroxybenzophenone-2, 4-dinitrophenylhydrazone (A-007) has recently completed a phase-I clinical trial, and objective responses were seen in advanced breast cancer, lung cancer, ovarian cancer, melanoma, skin cancer and non-Hodgkin's lymphoma. Despite the promising results in the...

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Bibliographic Details
Main Author: Sagiraju, Sarada
Format: Others
Published: ScholarWorks@UNO 2008
Subjects:
Cancer
Cyclodextrin
Inclusion complexes
A-007 prodrugs
Molecular aggregation
NOESY
ES mass spectroscopy
azlactone condensation
azlactone ring opening
oxazolones
tetramic acids
Magnesidin
Online Access:http://scholarworks.uno.edu/td/900
http://scholarworks.uno.edu/cgi/viewcontent.cgi?article=1881&context=td

Internet

http://scholarworks.uno.edu/td/900
http://scholarworks.uno.edu/cgi/viewcontent.cgi?article=1881&context=td

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