Identification of Mutations in the NS1 Gene That Control Influenza A Virus Virulence in the Mouse Model
The genetic requirements for Influenza virus to infect and adapt to new species is largely unknown. To understand the evolutionary steps required by a virus to become virulent, a human virus (A/HK/1/68) (HK), avirulent in mice, was subjected to 20 and 21 serial lung-to-lung passages in mouse. Sequen...
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| Language: | en |
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Université d'Ottawa / University of Ottawa
2012
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| Online Access: | http://hdl.handle.net/10393/23371 http://dx.doi.org/10.20381/ruor-6115 |