Predicting the Sensitivity of Avian Species to the Embryotoxic Effects of Polychlorinated Biphenyls (PCBs) Using 'in vitro' Approaches
The goal of this thesis was to use a luciferase reporter gene (LRG) assay in order to predict avian species sensitivity to the toxic effects of polychlorinated biphenyl (PCB) congeners 126, 77, 105 and 118 based on their aryl hydrocarbon receptor 1 (AHR1) ligand binding domain (LBD) sequence. These...
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| Language: | en |
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Université d'Ottawa / University of Ottawa
2012
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| Online Access: | http://hdl.handle.net/10393/23604 http://dx.doi.org/10.20381/ruor-6278 |