The Role of the E3-ubiquitin Ligase Trim17 in the Mitochondrial Cell Death Pathway
The upregulation of apoptosis is a hallmark of several neurodegenerative disorders including ischemic stroke. In neurons, as in other cell types, Bax and tBid are critical regulators of the intrinsic pathway upstream of mitochondrial outer membrane permeabilization (MOMP) and caspase activation. The...
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| Language: | en |
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Université d'Ottawa / University of Ottawa
2013
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| Online Access: | http://hdl.handle.net/10393/23715 http://dx.doi.org/10.20381/ruor-3531 |