Regulation of Neural Precursor Self-renewal via E2F3-dependent Transcriptional Control of EZH2

Our lab has recently found that E2F3, an essential cell cycle regulator, regulates the self-renewal capacity of neural precursor cells (NPCs) in the developing mouse brain. Chromatin immunoprecipitation (ChIP) and immunoblotting techniques revealed several E2F3 target genes, including the polycomb...

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Bibliographic Details
Main Author: Pakenham, Catherine
Other Authors: Slack, Ruth
Language:en
Published: Université d'Ottawa / University of Ottawa 2013
Subjects:
p16
Online Access:http://hdl.handle.net/10393/23812
http://dx.doi.org/10.20381/ruor-6468