GGTI-298 in Combination with EGFR Inhibitors: Evaluating a Novel Therapy in Head and Neck Squamous Cell Carcinomas

GGTI-298 in Combination with EGFR Inhibitors: Evaluating a Novel Therapy in Head and Neck Squamous Cell Carcinomas

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Overall survival of the metastatic forms of epithelial derived cancers, especially head and neck squamous cell carcinomas (HNSCC), has not significantly improved even with the application of aggressive combined modality approaches incorporating radiation and chemotherapy. Cumulative evidence implica...

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Bibliographic Details
Main Author: Zahr, Stephanie
Other Authors: Dimitroulakos, Jim
Language:en
Published: Université d'Ottawa / University of Ottawa 2013
Subjects:
head and neck cancers
head and neck squamous cell carcinomas
receptor tyrosine kinases
epidermal growth factor receptor
tyrosine kinase inhibitors
mevalonate pathway
statins
protein prenylation
geranylgeranylation
GTPase inhibitors
Online Access:http://hdl.handle.net/10393/25488
http://dx.doi.org/10.20381/ruor-3175

Internet

http://hdl.handle.net/10393/25488
http://dx.doi.org/10.20381/ruor-3175

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