Ex Vivo Evaluation of Myocardial Beta-Adrenergic Receptors in High-Fat Fed STZ and ZDF Models of Diabetes Using [3H]-CGP12177
Diabetes mellitus (DM) and hyperglycemia contribute to sympathetic nervous system (SNS) activation and cardiovascular dysfunction. SNS activation and increased norepinephrine levels downregulate cardiac β-adrenergic receptors (β-AR). The ADMIRE-HF trial identified reduced cardiac SNS innervation as...
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| Language: | en |
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Université d'Ottawa / University of Ottawa
2013
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| Online Access: | http://hdl.handle.net/10393/30363 http://dx.doi.org/10.20381/ruor-3397 |