The Role and Regulation of the Phosphatase PPM1D in Chemoresistant Gynecological Cancers
Cisplatin (CDDP; cis-diamminedichloroplatinum) resistance presents a major impediment in the treatment of several gynecologic solid tumors, including ovarian and cervical tumors. p53, a critical regulator of cellular apoptosis, is a determinant of CDDP sensitivity. In our study, we have observed tha...
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| Language: | en |
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Université d'Ottawa / University of Ottawa
2014
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| Online Access: | http://hdl.handle.net/10393/30489 http://dx.doi.org/10.20381/ruor-3512 |