Development of Inhibitors of Human PCSK9 as Potential Regulators of LDL-Receptor and Cholesterol

Development of Inhibitors of Human PCSK9 as Potential Regulators of LDL-Receptor and Cholesterol

Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) is the ninth member of the Ca+2-dependent mammalian proprotein convertase super family of serine endoproteases that is structurally related to the bacterial subtilisin and yeast kexin enzymes. It plays a critical role in the regulation of lipid metabo...

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Bibliographic Details
Main Author: Alghamdi, Rasha Hassen
Other Authors: Basak, Ajoy
Language:en
Published: Université d'Ottawa / University of Ottawa 2014
Subjects:
Proprotein Convertase Subtilisin/Kexin 9
PCSK9
Low Density Lipoprotein Receptor
LDL-R
Low Density Lipoprotein Cholesterol
LDL-C
Cardiovascular Disease
CVD
Autosomal Dominant Hypercholesterolemia
ADH
Catalytic Domain
Inhibitors
Peptides Design
LDL-R Degradation
Epidermal Growth Factor like repeat A
EGF-A
Familial Hypercholesterolemia
FH
Gain-of-Function Mutations
Online Access:http://hdl.handle.net/10393/30492
http://dx.doi.org/10.20381/ruor-5631

Internet

http://hdl.handle.net/10393/30492
http://dx.doi.org/10.20381/ruor-5631

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