Development of a Mathematical Model to Understand, Design & Improve Oncolytic Virus Therapies

Oncolytic viruses (OVs) are emerging as a potent therapeutic platform for the treatment of malignant disease. The tumor cells inability to induce antiviral defences in response to a small cytokine known as interferon (IFN) is a common defect exploited by OVs. Heterogeneity in IFN signalling across t...

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Bibliographic Details
Main Author: Batenchuk, Cory
Other Authors: Bell, John
Language:en
Published: Université d'Ottawa / University of Ottawa 2014
Subjects:
Online Access:http://hdl.handle.net/10393/31182
http://dx.doi.org/10.20381/ruor-3780