Characterization of [18F]FPyKYNE-Losartan as a Novel PET Tracer for Imaging AT1 Receptors

Characterization of [18F]FPyKYNE-Losartan as a Novel PET Tracer for Imaging AT1 Receptors

The Angiotensin II Type I Receptor (AT1R) is the main receptor that produces most of the physiological actions of the Renin Angiotensin System (RAS). Alterations of AT1R expression in renal and cardiovascular diseases make this receptor an attractive target for developing an imaging agent to monitor...

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Bibliographic Details
Main Author: Hachem, Maryam
Other Authors: DaSilva, Jean
Language:en
Published: Université d'Ottawa / University of Ottawa 2015
Subjects:
Angiotensin II Type 1 Receptor
AT1R
RAS
[18F]FPyKYNE-Losartan
Losartan
PET
Metabolites
Antagonism
Binding selectivity
Dosimetry
Online Access:http://hdl.handle.net/10393/32417
http://dx.doi.org/10.20381/ruor-4362

Internet

http://hdl.handle.net/10393/32417
http://dx.doi.org/10.20381/ruor-4362

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